DETECTION AND MONITORING OF SARS-CoV-2 RNA FRAGMENTS IN WASTEWATER USING A MALDI-TOF MASS SPECTROMETER

The purpose of this study is to develop an analytical test method for the detection and quantification of SARS-CoV-2 RNA fragments in sewer wastewater, using a MALDI-TOF mass spectrometer. With this technology, we intend to obtain test results within a few minutes, thus enabling us to confirm the…

Establishing a national COVID 19 wastewater and non-sewer based water quality survaillance programme

Surveillance of wastewater treatment plants offers an opportunity for near–real-time outbreak data and as an early warning for resurgence of the outbreak. To date, the wastewater-based epidemiology approach has been successfully piloted in developed countries where there is wide coverage of…

In vitro Molecular RNA-seq data for rapid diagonostic testing and validating RT-qPCR reference genes for studying respiratory specimens from Persons Under Investigation (PUIs), with Suspected or Confirmed Coronavirus Disease 2019 (COVID-19).

The SARS coronavirus (SCoV) appears to be zoonotic and to have originated in wild mammals in southern China. A coronavirus comprises single-stranded RNA inside a lipid envelope. Coronaviruses cause a substantial fraction of human colds and a number of common respiratory infections in other animals…

A 12-month Prospective study: A Self-reported outcome of South African population recovering from COVID-19 pandemic

The brief purpose of this study is to determine the patient-reported outcomes of participants recovering from COVID-19. This is a longitudinal study seeking to study the same population over a period of 12 months in intermittent timepoints. This study will collect data and assess the change in…

Wastewater-Based Epidemiology for Covid-19 Detection

The concept of wastewater-based epidemiology (WBE) has been used extensively for the detection of drug use patterns and disease incidence from a population perspective. Recently researchers have proposed SARS-CoV-2 sewage-monitoring plan as a form of an early warning system. It can have an…

Health facility-based observational studies to investigate interaction and overlap between SARS- CoV2, HIV-1 and M. tuberculosis infections (HIATUS)

This programme of projects is focused on understanding and providing information on the clinical presentation and pathogenesis of COVID-19 in the South African population.

Researchers in the HIATUS programme of four related projects will invite hospitalised COVID-19 patients to…

Coronavirus Disease 2019 and Endothelialitis

In the era of the global COVID-19 pandemic, questions remain about the pathophysiology, and the severity markers and potential treatment targets. In high HIV prevalence settings, the burden of COVID-19 is yet to be documented, and how these two pandemics will collide and interact remains to be seen…

WASTEWATER-BASED EPIDEMIOLOGY FOR COVID-19 DETECTION IN WASTEWATER

With the economic and practical limits of medical screening for SARS-CoV-2/COVID-19 coming sharply into focus worldwide, scientists are turning now to wastewater-based epidemiology (WBE) as a potential tool for assessing and managing the pandemic. This approach is built on the knowledge that some…

Dietary habits and health outcomes of African populations during COVID-19 lockdown

The objective of this research is to comparatively assess the changes in dietary habits of various populations during the COVID-19 lockdown and to also determine the effect this has on people’s health. As a result of the lockdown situation to combat the spread of COVID-19, movements have been…

Surrogate Assisted Agent Based Modelling of Epidemics

There is a pressing need to rapidly simulate accurate complex conceptual models (Agent-based Models) for the spread of an epidemic within a population. Accurate agent-based models allow for thorough scenario planning allowing on to simulate the impact of extensive external factors. This research…

SAPRIN Covid-19 Surveillance

A coordinated system of disease surveillance will be critical to effectively control the coronavirus disease 2019 (Covid-19) pandemic. Such systems enable rapid detection and mapping of epidemics and inform allocation of scarce prevention and intervention resources. Although many lower- and middle-…

Measuring Social Contact in Rural KwaZulu-Natal during the Covid-19 Epidemic

We aim to identify the impact of government regulations for COVID-19 on social interaction and behaviour. To achieve this we will interview 400 residents of the Africa Health Research Institute Population Intervention Platform area in northern KwaZulu-Natal. These interviews will be repeated every…