DETECTION AND MONITORING OF SARS-CoV-2 RNA FRAGMENTS IN WASTEWATER USING A MALDI-TOF MASS SPECTROMETER

The purpose of this study is to develop an analytical test method for the detection and quantification of SARS-CoV-2 RNA fragments in sewer wastewater, using a MALDI-TOF mass spectrometer. With this technology, we intend to obtain test results within a few minutes, thus enabling us to confirm the…

Identification of potential SARS-CoV-2 inhibitors from South African medicinal plant

-Our team identified compounds found in South African indigenous plants that would target SARS-CoV-2 using molecular docking
-We want to now take this further and commence In vitro studies as well as in vivo rat models

Quarantuning at the time of Coronavirus

This research project looks at how Quarantine was used as a preventative measure in the fight against Covid-19. It seeks to asses the impact of Quarantine towards flattening the curve. It also delves deeper into the concept of Quarantine and how South Africans got to experience it and apply it in…

Clinical effectiveness of lopinavir in the management of Covid-19 infection and prevention.

COVID-19 also known as Coronavirus 2019, is currently declared by WHO as a new pandemic
disease caused by a single-stranded RNA zoonotic virus termed severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) (Lu et al. 2020). The complete viral genome analysis shows that the…

Establishing a national COVID 19 wastewater and non-sewer based water quality survaillance programme

Surveillance of wastewater treatment plants offers an opportunity for near–real-time outbreak data and as an early warning for resurgence of the outbreak. To date, the wastewater-based epidemiology approach has been successfully piloted in developed countries where there is wide coverage of…

In vitro Molecular RNA-seq data for rapid diagonostic testing and validating RT-qPCR reference genes for studying respiratory specimens from Persons Under Investigation (PUIs), with Suspected or Confirmed Coronavirus Disease 2019 (COVID-19).

The SARS coronavirus (SCoV) appears to be zoonotic and to have originated in wild mammals in southern China. A coronavirus comprises single-stranded RNA inside a lipid envelope. Coronaviruses cause a substantial fraction of human colds and a number of common respiratory infections in other animals…

Understanding Droplet Transmission in a clinical environment

This project performs a Continuum Fluid Dynamics CFD study of droplet based transmission and airborne transmission for Tuberculosis (TB) and COVID-19 scenarios in real clinical environments. The study focuses on the probability of infection for either disease as a function of the environment and…

Artificial Intelligence and Diagnosis based on Multiple Data Sources

This project is a large interdisciplinary partnership of Doctors, Public Health Researchers, Data Scientists, Physicists and Engineers. It combines the data sets represented by several sources, including images of chest X-rays, audio recordings of coughs and set sentences, and Natural Language…

Understanding Droplet Transmission in a Taxi

This project performs a Continuum Fluid Dynamics CFD study of droplet based transmission and airborne transmission for Tuberculosis (TB) and COVID-19 scenarios in a Taxi environments. The final goal of the study is to guide development of disruptive and innovative interventions for a Taxi to…

A 12-month Prospective study: A Self-reported outcome of South African population recovering from COVID-19 pandemic

The brief purpose of this study is to determine the patient-reported outcomes of participants recovering from COVID-19. This is a longitudinal study seeking to study the same population over a period of 12 months in intermittent timepoints. This study will collect data and assess the change in…

Wastewater-Based Epidemiology for Covid-19 Detection

The concept of wastewater-based epidemiology (WBE) has been used extensively for the detection of drug use patterns and disease incidence from a population perspective. Recently researchers have proposed SARS-CoV-2 sewage-monitoring plan as a form of an early warning system. It can have an…

What is South Africa’s healthcare response to COVID-19: A mapping and situational analysis study

This study is comprised of three sub-studies that together make up our research into the healthcare response to COVID-19.

Firstly, we will conduct a policy review: to identify and analyse what the South African health policy and guideline documents specify as ‘the response’ in…